Matthew James Moscou
0000-0003-2098-6818
D-5266-2011
Address
The Sainsbury Laboratory
Norwich Research Park
Norwich
NR4 7UH
United Kingdom
Contact information
Office: +44 (0) 1603 450 296
Email: matthew.moscou@sainsbury-laboratory.ac.uk
Education
Iowa State University, Bioinformatics and Computational Biology, Ph.D., 2010
University of California, Riverside, Pure Mathematics, B.S., 2004
University of California, Riverside, Physics, B.S., 2004
Dissertation
Deciphering the transcriptional regulation and response of barley to obligate fungal biotroph invasion
Advisors: Roger Wise and Julie Dickerson
Professional Experience
2018-present Honorary Lecturer, University of East Anglia, UK
2014-present Group Leader, The Sainsbury Laboratory, UK
2013-2014 Team Leader, 2Blades Group, The Sainsbury Laboratory, UK
2010-2012 Post-doctoral Research Associate, 2Blades Group, The Sainsbury Laboratory, UK
2005-2010 Graduate Research Assistant, Iowa State University
Summer 2009 Summer Intern, Syngenta Seeds, Inc. – Statistical Genetics Research Group
2004-2005 Programmer/Analyst I, University of California, Riverside
Teaching, Mentoring, and Supervision
Supervisor of seven Ph.D. and nine Msc students (TSL, 2011-present)
Lecturer at the Instituto de Tecnologia Química e Biológica António Xavier (2019)
The Sainsbury Laboratory Summer School, Lecturer (TSL, 2012, 2015, 2017)
Lecturer at the University of East Anglia for BIO-03C46 (Plant Biotechnology for Sustainable Food Production) (UEA, 2015)
EMBO Practical Course on Plant-Microbe Interactions, Lecturer (TSL, 2012)
Molecular Biology of Plant-Pathogen Interaction, Guest Lecturer (ISU, 2008)
Computational and Systems Biology Summer Institute, Lecturer/Teaching Assistant (ISU, 2007)
National Science Foundation, Research Experience for Teachers, Mentor (ISU, 2006)
Bioinformatics and Computational Biology Summer Institute, Lecturer/Teaching Assistant (ISU, 2006)
Fellowships and Awards
Human Frontier Science Program Fellow, Long-Term Fellowship, 2011-2014
Graduate Research Excellence Award, Iowa State University, 2010
BioVision.Nxt Fellow, 2009
James Cornette Research Fellowship in Bioinformatics and Computational Biology, Iowa State University, 2008
Preprints
Brabham, H. J., Hernández-Pinzón, I., Holden, S., Lorang, J., and Moscou, M.J. (2017) An ancient integration in a plant NLR is maintained as a trans-species polymorphism. bioRxiv 239541 doi:10.1101/239541
Clare, S., Kitcher, W., Gardiner, M., Green, P., Hubbard, A., and Moscou, M.J. (2016) Defining the genetic architecture of stripe rust resistance in the barley accession HOR 1428. bioRxiv 093773 doi:10.1101/093773
Publications
2020
Panstruga, R. and Moscou, M.J. (2020) What is the molecular basis of nonhost resistance? Molecular Plant-Microbe Interactions doi:10.1094/
Read, A.C.
, Hutin, M., Moscou, M.J., Rinaldi, F.C., and Bogdanove, A. J. (2020) Cloning of the rice Xo1 resistance gene and interaction of the Xo1 protein with the defense-suppressing Xanthomonas effector Tal2h Molecular Plant-Microbe Interactions doi:10.1094/MPMI-05-20-0131-SC
Hiebert, C.W., Moscou, M.J., Hewitt, T., Steuernagel, B., Hernández-Pinzón, I., Green, P., Pujol, V., Zhang, P., Rouse, M.N., Jin, Y., McIntosh, R.A., Upadhyaya, N., Zhang, J., Bhavani, S., Vrána, J., Karafiátová, M., Huang, L., Fetch, T., Doležel, J., Wulff, B.B.H., Lagudah, E., Spielmeyer, W. (2020) Stem rust resistance in wheat is suppressed by a subunit of the Mediator complex Nature Communications doi:10.1038/s41467-020-14937-2
Wei, B., Moscou, M.J., Sato, K., Gourlie, R., Strelkov, S., Aboukhaddour, R. (2020) Identification of a locus conferring dominant susceptibility to Pyrenophora tritici-repentis in barley. Frontiers in Plant Science doi:10.3389/fpls.2020.00158
2018
Bettgenhaeuser, J., Gardiner, M., Spanner, R., Green, P., Hernández-Pinzón, I., Hubbard, A., Ayliffe, M., and Moscou, M.J. (2018) The genetic architecture of colonization resistance in Brachypodium distachyon to non-adapted stripe rust (Puccinia striiformis) isolates. PLoS Genetics 14(9):e1007637. doi:10.1371/journal.pgen.1007637
Gilbert, B., Bettgenhaeuser, J., Upadhyaya, N., Soliveres, M., Singh, D., Park, R.F., Moscou, M.J., and Ayliffe, M. (2018) Components of Brachypodium distachyon resistance to the nonadapted wheat stripe rust pathogens are simply inherited. PLoS Genetics 14(9):e1007636. doi:10.1371/journal.pgen.1007636
Ghosh, S., Watson, A., Gonzalez-Navarro, O.E., Ramirez-Gonzalez, R.H., Yanes, L., Mendoza-Suarez, M., Simmonds, J., Wells, R., Rayner, T., Green, P., Hafeez, A., Hayta, S., Melton, R.E., Steed, A., Sarkar, A., Carter, J., Perkins, L., Lord, J., Tester, M., Osbourn, A., Moscou, M.J., Nicholson, P., Harwood, W., Martin, C., Domoney, C., Uauy, C., Hazard, B., Wulff, B.B.H., Hickey, L.T. (2018) Speed breeding in growth chambers and glasshouses for crop breeding and model plant research. Nature Protocols 13:2944-2963. doi:10.1038/s41596-018-0072-z
Omidvar, V., Dugyala, S., Li, F., Rottschaefer, S., Miller, M.E., Ayliffe, M., Moscou, M.J., Kianian, S.F., Figueroa, M. (2018) Detection of race-specific resistance against Puccinia coronata f. sp. avenae in Brachypodium species. Phytopathology Accepted. doi:10.1094/PHYTO-03-18-0084-R
Bailey, P.C., Schudoma, C., Jackson, W., Baggs, E., Dagdas, G., Haerty, W., Moscou, M., Krasileva, K.V. 2018. Dominant integration locus drives continuous diversification of plant immune receptors with exogenous domain fusions. Genome Biology 19:23. doi:10.1186/s13059-018-1392-6
2017
Moscou, M. J. and van Esse, H. P. (2017) The quest for durable resistance. Science 358:1541-1542. doi:10.1126/science.aar4797
Herb, D.W., Benson, A., Carey, D., Cistue, L., Filichkin, T, Fisk, S.P., Helgerson, L., Jennings, R., Li, Y., Meints, B.M., Monsour, R., Moscou, M., Nguygen, A., Onio, A., Romagosa, I., Thiel, R., Thomas, W.B., Tynan, S.P., Vega, V., Vinkemeier, K., Hayes, P.M. (2017) Malt modification and its effects on the contributions of barley genotype to beer flavor. Journal of American Society of Brewing Chemists. 4:354-362 doi:10.1094/ASBCJ-2017-4976-01
Herb, D.W., Meints, B.M., Jennings, R., Romagosa, I., Moscou, M., Carey, D., Cistue, L., Filichkin, T, Fisk, S.P., Helgerson, L., Martens, C., Monsour, R., Thiel, R., Tynan, S., Thomas, W.T.B., Vinkemeier, K., Hayes, P.M. 2017. Effects of barley (Hordeum vulgare L.) variety and growing environment on beer flavor. Journal of American Society of Brewing Chemists. 4:345-353 doi:10.1094/ASBCJ-2017-4860-01
Yu, G., Champouret, N., Steuernagel, B., Olivera, P.D., Simmons, J. Williams, C. Johnson, R., Moscou, M.J., Hernández-Pinzón, I., Green, P., Sela, H., Millet, E., Jones, J.D.G., Ward, E.R., Steffenson, B.J., and Wulff, B.B.H. (2017) Discovery and characterization of two new stem rust resistance genes in Aegilops sharonensis. Theoretical and Applied Genetics 130:1207–1222 doi:10.1007/s00122-017-2882-8
Hisano, H., Meints, B., Moscou, M.J., Cistue, L., Echávarri, B., Sato, K., and Hayes, P.M. (2017) Selection of transformation-efficient barley genotypes based on TFA (transformation amenability) haplotype and higher resolution mapping of the TFA loci. Plant Cell Reports 36:611–620 doi:10.1007/s00299-017-2107-2
Bettgenhaeuser, J., Corke, F.M.K., Opanowicz, M., Green, P., Hernández-Pinzón, I., Doonan, J.H., Moscou, M.J. (2017) Natural variation in Brachypodium links vernalization and flowering time loci as major flowering determinants. Plant Physiology 173:256-268 doi:10.1104/pp.16.00813
2016
Le Fevre, R., O’Boyle, B., Moscou, M.J., and Schornack S. (2016) Colonization of barley by the broad-host hemibiotrophic pathogen Phytophthora palmivora uncovers a leaf development dependent involvement of MLO. Molecular Plant-Microbe Interactions 29: 385-395 doi:10.1094/MPMI-12-15-0276-R
Dawson, A.M., Ferguson, J., Gardiner, M., Green, P., Hubbard, A., and Moscou, M.J. (2016) Isolation and fine mapping of Rps6: An intermediate host resistance gene in barley to wheat stripe rust. Theoretical and Applied Genetics 129: 831-843 doi:10.1007/s00122-015-2659-x
2015
Dawson, A.M., Bettgenhaeuser, J., Gardiner, M., Green, P., Hernández-Pinzón, I., Hubbard, A., and Moscou, M.J. (2015) The development of quick, robust, quantitative phenotypic assays for describing the host-nonhost landscape to stripe rust. Frontiers in Plant Science 6: 876 doi:10.3389/fpls.2015.00876
Muñoz-Amatriaín, M., Lonardi, S., Luo, M. C., Madishetty, K., Svensson, J.T., Moscou, M.J., Wanamaker, S., Jiang, T., Kleinhofs, A., Muehlbauer, G.J., Wise, R., Stein, N., Ma, Y., Rodriguez, E., Kudrna, D., Bhat, P., Chao, S., Condamine, P., Heinen, S., Resnik, J., Wing, R., Witt, H., Alpert, M., Beccuti, M., Bozdag, S., Cordero, F., Mirebrahim, H., Ounit, R., Wu, Y., You, F., Zheng, J., Doležel, J., Grimwood, J., Schmutz, J., Duma, D., Altschmied, L., Blake, T., Bregitzer, P., Cooper, L., Dilbirligi, M., Falk, A., Feiz, L., Graner, A., Gustafson, P., Hayes, P.M., Lemaux, P., Mammadov, J., and Close, T.J. (2015) Sequencing of 15 622 gene-bearing BACs clarifies the gene-dense regions of the barley genome. The Plant Journal 84: 216-227 doi:10.1111/tpj.12959
Knight, E., Binnie, A., Draeger, T., Moscou, M., Rey, M., Sucher, J., Mehra, S., King, I., and Moore, G. (2015) Mapping the ‘breaker’ element of the gametocidal locus proximal to a block of sub-telomeric heterochromatin on the long arm of chromosome 4Ssh of Aegilops sharonensis. Theoretical and Applied Genetics 128(6):1049-1059 doi:10.1007/s00122-015-2489-x
2014
Wulff, B.H.H. and Moscou, M.J. (2014) Strategies for transferring resistance into wheat: from wide crosses to GM cassettes. Frontiers in Plant Science 5:692 doi:10.3389/fpls.2014.00664
Bettgenhaeuser, J., Gilbert, M., Ayliffe, M., Moscou, M.J. (2014) Nonhost resistance to rust pathogens – a continuation of continua. Frontiers in Plant Science 5:664 doi:10.3389/fpls.2014.00664
2013
Bouyioukos, C., Moscou, M.J., Champouret, N., Hernández-Pinzón I., Ward E.R. and Wulff B.B.H. (2013) Characterisation and analysis of the Aegilops sharonensis transcriptome, a wild relative of wheat in the Sitopsis section. PLoS ONE 8(8): e72782. doi:10.1371/journal.pone.0072782
Ayliffe, M. Singh, D., Park, R., Moscou, M., Pryor, T. (2013) The infection of Brachypodium distachyon with selected grass rust pathogens. Molecular Plant-Microbe Interactions 26(8): 946-957 doi:10.1094/MPMI-01-13-0017-R
Schornack, S., Moscou, M.J., Ward, E.R., and Horvath, D. M. (2013) Engineering plant disease resistance based on TAL effectors. Annual Review of Phytopathology 51:383-406 doi:10.1146/annurev-phyto-082712-102255
2012
The International Barley Genome Sequencing Consortium (IBSC). (2012) A physical, genetic and functional sequence assembly of the barley genome. Nature 491: 711-716 doi:10.1038/nature11543
Moeller, J.R., Moscou, M.J., Bancroft, T., Skadsen, R.W., Wise, R.P., and Whitham, S.A. (2012) Differential accumulation of host mRNAs on polyribosomes during obligate pathogen-plant interactions. Molecular BioSystems 8:2153-2165 doi:10.1039/C2MB25014D
2011
Muñoz-Amatriaín, M., Moscou, M.J., Bhat, P.R., Svensson, J.T., Bartoš, J., Suchánková, P., Šimková, H., Endo, T.R., Fenton, R. D., Wu, Y., Lonardi, S., Castillo, A.M., Chao, S., Cistué, L., Cuesta-Marcos, A., Forrest, K., Hayden, M.J., Hayes, P.M., Horsley, R.D., Kleinhofs, A., Moody, D., Sato, K., Vallés, M.P., Wulff, B.B.H., Muehlbauer, G.J., Doležel, J., and Close, T.J. (2011) An improved consensus linkage map of barley based on flow-sorted chromosomes and SNP markers. The Plant Genome 4(3): 238-249 doi:10.3835/plantgenome2011.08.0023
Moscou, M.J., Lauter, N., Steffenson, B., and Wise, R.P. (2011) Quantitative and qualitative stem rust resistance factors in barley are associated with transcriptional suppression of defense regulons. PLoS Genetics 7(7): e1002208 doi:10.1371/journal.pgen.1002208
Moscou, M.J., Lauter, N., Caldo, R.A., Nettleton, D., and Wise, R.P. (2011) Quantitative and temporal definition of the Mla transcriptional regulon during barley-powdery mildew interactions. Molecular Plant-Microbe Interactions 24(6): 694-705 doi:10.1094/MPMI-09-10-0211
2009
Close, T.J., Bhat, P.R., Lonardi, S., Wu, Y., Rostoks, N., Ramsay, L., Druka, A., Stein, N., Svensson, J.T., Wanamaker, S., Bozdag, S., Roose, M.L., Moscou, M.J., Chao, S., Varshney, R., Szűcs, P., Sato, K., Hayes, P.M., Matthews, D.E., Kleinhofs, A., Muehlbauer, G. J., DeYoung, J., Marshall, D.F., Madishetty, K., Fenton, R.D., Condamine, P., Graner, A., Waugh, R. 2009. Development and implementation of high-throughput SNP genotyping in barley. BMC Genomics 10: 582 doi:10.1186/1471-2164-10-582
Moscou, M.J. and Bogdanove, A. (2009) A simple cipher governs DNA recognition by TAL effectors. Science 326: 1501 doi:10.1126/science.1178817
Xi, L., Moscou, M.J., Meng, Y., Xu, W. Caldo, R.A., Shaver, M., Nettleton, D., Wise, R.P. (2009) Transcript-based cloning of HvRRP46, a regulator of rRNA processing and R gene-independent cell death in barley-powdery mildew interactions. Plant Cell 21: 3280-3295 doi:10.1105/tpc.109.066167
Meng, Y., Moscou, M.J., Wise, R.P. (2009) Blufensin1 negatively impacts basal defense in response to barley powdery mildew. Plant Physiology 149(1): 271-285 doi:10.1104/pp.108.129031
2008
Lauter, N., Moscou, M.J., Habinger, J., Moose, S. (2008) Quantitative genetic dissection of shoot architecture traits in maize: Towards a functional genomics approach. The Plant Genome 1(2): 99-110 doi:10.3835/plantgenome2008.06.0385
Potokina, E., Druka, A., Luo, Z., Moscou, M., Wise, R., Waugh, R., Kearsey, M. (2008) Tissue-dependent limited pleiotropy affects gene expression in barley. Plant Journal 56(2): 287-296 doi:10.1111/j.1365-313X.2008.03601.x
2007
Wise, R.P., Moscou, M.J., Bogdanove, A.J., Whitham, S.A. (2007) Transcript profiling in host–pathogen interactions. Annual Review of Phytopathology 45: 329-369 doi:10.1146/annurev.phyto.45.011107.143944
Conference Publications
Champouret N, Moscou MJ, Bouyioukos C, Steuernagel B, Hernández-Pinzón I, Green P, Kaufman J, Olivera PD, Pretorius Z, Millet E, Steffenson BJ, Ward ER and Wulff BBH (2011) A pipeline for cloning resistance genes effective against African stem rust races from the diploid wheat relative Aegilops sharonensis In: Proc Borlaug Global Rust Initiative, June 13–19. McIntosh, R. (ed). pp. 66–74
Wise, R. P., Meng, Y., Moscou, M. J., Xu, W. 2009. Regulators of innate immunity in cereal-fungal interactions. In Biology of Plant Microbe Interactions, Volume 7. International Society for Molecular Plant-Microbe Interactions, St. Paul, MN
Moscou, M.J., Caldo, R.A., Lauter, N., Wise, R.P. 2008. Construction of coexpression networks to explore barley-powdery mildew interactions. Paper 113 in: Biology of Plant Microbe Interactions, Volume 6. M. Lorito, S. L. Woo, and F. Scala, eds. International Society for Molecular Plant-Microbe Interactions, St. Paul, MN
Invited Talks
An ancient integration at Mla is maintained as a trans-species polymorphism. Max Planck for Plant Breeding. Colonge, Germany. December 7, 2017.
The Mla locus: A nexus of multiple pathogen recognition. Powdery Mildew Genomics Workshop. Eger, Hungary. September 15, 2017.
Dissecting the genetic architecture of nonhost resistance to stripe rust. RWTH Aachen University. Aachen, Germany. June 7, 2017
Dissecting the genetic architecture of nonhost resistance to stripe rust. Institut de Recherche pour le Développement. Montpellier, France. April 21, 2017
The process of discovery: How a conversation at a conference led to the development of a research program. Plant Sciences Graduate Student Symposium. Saskatoon, Saskatchewan, Canada. April 1, 2017
Dissecting the genetic architecture of nonhost resistance to stripe rust. University of Saskatchewan. Saskatoon, Saskatchewan, Canada. March 30, 2017
Accessing natural variation in Brachypodium distachyon: Development of the ABR6 x Bd21 RIL population. Plant and Animal Genome Conference. San Diego, CA, USA. January 17, 2017
Genomics of the barley immune system. Plant and Animal Genome Conference. San Diego, CA, USA. January 14, 2017
Engineering durable disease resistance. Gatsby Plant Science Network Meeting. Oxford, United Kingdom. September 9, 2016
Dual specificity at the Mla locus confers resistance to barley powdery mildew and wheat stripe rust. International Powdery Mildew Symposium. Portland, Oregon, USA. July 16, 2016
The barley ‘nibblerome’: Defining the set of NB-LRR-type R genes from a diverse collection of barley. International Barley Genetics Symposium. Minneapolis, Minnesota, USA. June 28, 2016
Map-based cloning of host and nonhost resistance genes in barley. USDA-ARS, Cereal Crops Research Unit, North Dakota State University, Fargo, North Dakota, USA, December 1, 2015
Dissecting the genetic architecture of nonhost resistance to stripe rust. Plant Biotic Stresses & Resistance Mechanisms II, Vienna, Austria. July 3, 2015
Dissecting the basis of host species specificity and nonhost resistance to wheat stripe rust. Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany. November 24, 2014
Nonhost resistance as a potential source for controlling wheat rust disease. International Congress on Molecular Plant-Microbe Interactions, Rhodes, Greece. July 10, 2014
Harnessing the loci that determine the inappropriate host status of barley to engineer durable resistance to wheat stripe rust. North American Barley Researcher Workshop, Minneapolis, Minnesota, USA. July 2, 2014
Why does wheat stripe rust not infect barley? Plant and Animal Genome Conference, San Diego, California, USA. January 11, 2014
Deciphering the genetic architecture of host species specificity and nonhost resistance to wheat stripe rust. Oregon State University, Corvallis, Oregon, USA. January 8, 2014
The genetic architecture underlying host species specificity of stripe rust. Washington State University, Pullman, Washington, USA. January 6, 2014
Harnessing the loci underlying host species specificity to engineer durable resistance to wheat stripe rust. Keystone Symposia: Plant Immunity: Pathways and Translation. Big Sky, Montana, USA. April 7th-April 12th, 2013
Host species specificity to stripe rust in barley colocalizes with loci conditioning resistance to powdery mildew. University of Minnesota, St. Paul, Minnesota, USA. March 28th, 2013
spst1, a novel susceptibility gene in barley to wheat stripe rust. 13th International Cereal Rust and Powdery Mildew Conference. Beijing, China. August 28th-September 1st, 2012
Microscopy-based quantitative analysis of nonhost resistance in Brachypodium distachyon to cereal rusts. Monogram Conference. Aberystwyth, United Kingdom. March 26th-28th, 2012
Epistatic control of powdery mildew-induced necrosis among progeny of the Steptoe x Morex doubled-haploid mapping population in barley. John Innes Centre (JIC), Norwich, United Kingdom. March 17, 2009
Natural genetic variation in barley identifies master regulatory loci of defense-related genes. Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany. March 19, 2008
Gene-for-gene-mediated transcriptome reprogramming in barley-powdery mildew interactions. Plant and Animal Genome Conference, San Diego, California, USA. January 12, 2008
Bioinformatics and Computational Biology Laboratory: An interaction model for cross-departmental bioinformatics knowledge integration (http://lab.bcb.iastate.edu). New Mexico State University, Las Cruces, New Mexico, USA. November 14, 2007
PLEXdb: Plant and pathogen expression database and tools for comparative and functional genomics analysis. COST Action 858, INRA, Bordeaux, France. November 20, 2006
Markermaker: an iterative algorithm for optimization of fit between expression level polymorphisms and genetic marker datasets. Sixth Annual Joint Bioinformatics Symposium, Iowa State University, Ames, Iowa, USA. July 14, 2006
Peer Review
Manuscripts reviewed for BMC Genomics, BMC Plant Biology, Frontiers in Plant Science, Genome Biology, Journal of Experimental Botany, Molecular Genetics and Genomics, Molecular Plant Pathology, Nature Communications, Nature Genetics, Physiological and Molecular Plant Pathology, Phytopathology, Plant Cell Reports, Plant Health Progress, Plant Management Network, PLoS Genetics, PLoS ONE, Rice, Science, and Theoretical and Applied Genetics.
Membership in Professional Societies
American Association for the Advancement of Science
American Society of Plant Biologists
British Society of Plant Pathology
Genetics Society of America
International Society of Molecular Plant-Microbe Interactions
Last updated: 2020 November 30